General Information

  • ID:  hor002896
  • Uniprot ID:  B3EWM8
  • Protein name:  Neuropeptide CCHamide-1
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  NA
  • Source:  animal
  • Expression:  Detected in larvae. |Expressed in the midgut but not in the ring gland, CNS, thoracic perisympathetic organs (tPSO) and abdominal perisympathetic organs (aPSO) (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  SCLEYGHSCWGAH
  • Length:  13(1-13)
  • Propeptide:  SCLEYGHSCWGAH
  • Signal peptide:  NA
  • Modification:  T13 Histidine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45697
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002896_AF2.pdbhor002896_ESM.pdb

Physical Information

Mass: 166381 Formula: C62H84N18O19S2
Absent amino acids: DFIKMNPQRTV Common amino acids: CGHS
pI: 6.48 Basic residues: 2
Polar residues: 7 Hydrophobic residues: 3
Hydrophobicity: -30 Boman Index: -957
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 37.69
Instability Index: 6484.62 Extinction Coefficient cystines: 7115
Absorbance 280nm: 592.92

Literature

  • PubMed ID:  22848525
  • Title:  Peptidomics of the Agriculturally Damaging Larval Stage of the Cabbage Root Fly Delia Radicum (Diptera: Anthomyiidae)